CHX |
Reversible |
Binds E site, 60S ribosome subunit |
Blocks translocation during elongation; stabilizes polysomes |
Schneider-Poetsch et al., 2010 |
Emetine |
Irreversible |
Binds 40S ribosome subunit |
Freezes translation during elongation; stabilizes polysomes |
Jiménez et al., 1977 |
Anisomycin |
Reversible |
Binds A site, 60S ribosome subunit; competes with PMY |
Blocks peptidyl transferase activity; stabilizes polysomes |
Hansen et al., 2003 |
Pactamycin |
Reversible |
Binds 40S ribosome subunit in initiation complex |
Blocks initiation step of translation; inhibits polysome formation |
Kappen et al., 1973 |
Sodium arsenite |
Reversible |
Oxidative stressor induces eIF2a phosphorylation |
Induces stress granule; inhibits polysome formation |
Kedersha et al., 2002 |
Harringtonine |
Partially reversible |
Prevents peptide bond formation at the initiation complex |
Blocks initiation step of translation; inhibits polysome formation |
Fresno et al., 1977 |