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. 2012 Apr 2;197(1):11–18. doi: 10.1083/jcb.201108006

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© 2012 Mardin and Schiebel

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Figure 2. — Centriole disengagement and duplication. Main players of centriole disengagement are depicted. During mitosis, Plk1 and separase consecutively disjoin mother and daughter centrioles. In addition, Plk1-mediated modification of the centrioles defines their capability of becoming a fully functional centrosome. In late mitosis the main centriole assembly factor hSas-6 is degraded and its levels are kept low by APC/C- and SCF-mediated proteolysis until the duplication can be initiated. In addition, activation of Plk-4 inhibits this negative regulation to allow cartwheel formation.