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. 2012 Apr 2;197(1):11–18. doi: 10.1083/jcb.201108006

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© 2012 Mardin and Schiebel

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Figure 3. — Centrosome separation before and after NEBD. Plk1 has a central role in regulating the centrosome separation via different pathways. In G2, Plk1 activates Nek9/6/7 cascade to regulate the accumulation of Eg5. Moreover, Cdk1 is important for Eg5 binding to MTs. After NEBD, Plk1 regulates the phospho-balance on the centrosomal linker by controlling the association of Nek2 with PP1γ through phosphorylation of Mst2. In addition, Plk1 is involved in the targeting of Eg5 to the spindle poles.