Figure 3.
The effect of long-term acetate supplementation on brain histone deacetylase and histone acetyltransferase activities in control rats (aCSF), rats subjected to neuroinflammation (LPS) and rats treated with either water (H2O) or glyceryl triacetate (GTA). (A) Represents changes in brain HAT, and (B) represents changes in HDAC activities. HAT enzyme activity is expressed as the means ± SD of absorbance reading at 450 nm after 4 hours of incubation at 37°C, normalized to the protein assayed (μg). HDAC enzyme activity is expressed as the means ± SD of absorbance at 405 nm after 75 minutes of incubation at 37°C, normalized to the protein assayed (μg). Statistical significance (*compared to aCSF + H2O controls) was set at P ≤ 0.05, as determined by nonparametric one-way ANOVA followed by Dunn's post-hoc test.