Table 1.
Mutagenic activity (mean of the number of revertants/plate ± SD) of the bacterial strains TA98, TA100, TA97a and TA102 exposed to Dipteryx alata Vogel hydroalcoholic extract, at various concentrations, with (+S9) or without (-S9) metabolic activation
| Treatment (mg/plate) |
TA98 | TA100 | TA97a | TA102 | ||||
|---|---|---|---|---|---|---|---|---|
| - S9 | + S9 | - S9 | + S9 | - S9 | + S9 | - S9 | + S9 | |
| 0* | 25 ± 1.0 | 23 ± 2.5 | 155 ± 5.9 | 207 ± 19.0 | 197 ± 3.5 | 188 ± 121 | 275 ± 14.5 | 200 ± 9.0 |
| 3.6 | - | - | - | 201 ± 23.5 (0.9) | 227 ± 10.8* (1.2) | 213 ± 9.9 (1.1) | 229 ± 31.8 (0.9) | 277 ± 26.9 (1.4) |
| 4.7 | 25 ± 1.0 (1.0) | 23 ± 2.9 (1.0) | 135 ± 4.0 (0.9) | - | - | - | - | - |
| 7.1 | - | - | - | 238 ± 16.5 (1.1) | 203 ± 13.5 (1.0) | 199 ± 3.5 (1.1) | 218 ± 12.1 (0.9) | 299 ± 4.6* (1.5) |
| 9.4 | 40 ± 8.7* (1.6) | 24 ± 2.7 (1.0) | 149 ± 10.0 (0.9) | - | - | - | - | - |
| 14.1 | - | - | - | 220 ± 14.8 (1.1) | 201 ± 18.9(1.0) | 198 ± 12.0 (1.1) | 223 ± 3.5 (0.9) | 303 ± 5.5* (1.5) |
| 18.8 | 31 ± 4.4 (1.2) | 23 ± 2.0 (1.0) | 193 ± 11.7 (1.3) | - | - | - | - | - |
| 21.2 | - | - | - | 190 ± 16.9 (0.9) | 158 ± 31.2 (0.8) | 188 ± 7.4 (1.0) | 204 ± 15.0 (0.7) | 291 ± 1.5 (1.4) |
| 28.2 | 38 ± 2.9* (1.5) | 23 ± 2.1 (1.0) | 208 ± 14.0 (1.3) | - | - | - | - | - |
| 37.6 | 32 ± 6.7 (1.3) | 23 ± 2.1 (1.0) | 226 ± 40.0* (1.5) | - | - | - | - | - |
| Control + | 2757 ± 208.5d | 879 ± 46.1a | 923 ± 134.6b | 1357 ± 10.6 a | 1470 ± 85.9 d | 1210 ± 14.5 a | 1733 ± 149.7 c | 1280 ± 15.3 a |
-: not assayed; 0*: negative control (DMSO, 100 μL/plate); Control +: positive control; a 2-Anthramine (1.25 μg/plate); b Sodium azide (1.25 μg/plate); c Mitomycin (0.5 μg/plate); d4-nitro-o-phenylenediamine (10.0 μg/plate); * p < 0.05 (ANOVA). The values in brackets represent the mutagenic index.