Table 1. Baseline characteristics and hemodynamics of rats fed for 1 month a control (CD) or a cafeteria (CafD) diet.
Number of rats evaluated (CD/CafD) | CD | CafD | p | |
Body weight (g): Baseline | 7/7 | 240±5 | 239±4 | 0.850 |
Body weight (g): 4 weeks | 7/7 | 307±5 | 328±6 | 0.001 |
Liver weight (g) | 7/7 | 9.1±0.3 | 11.1±0.4 | <0.001 |
% liver/total weight | 7/7 | 2.9±0.1 | 3.3±0.1 | 0.005 |
Blood glucose (mg/dL) | 4/4 | 117±8 | 151±10 | 0.003 |
Plasma insulin (µU/mL) | 4/4 | 35.9±4.5 | 56.9±8.4 | 0.004 |
Bilirubin (mg/dl) | 4/4 | 0.10±0.04 | 0.28±0.10 | 0.033 |
AST (U/L) | 4/4 | 85±14 | 88±8 | 0.656 |
ALT (U/L) | 4/4 | 52±9 | 32±6 | 0.014 |
Plasma FFA (µM) | 4/4 | 1613±274 | 3214±334 | 0.001 |
Plasma Triglycerides (mg/dL) | 4/4 | 75±13 | 200±42 | 0.026 |
Liver FFA (umol*g liver-1) | 4/4 | 9.2±1.1 | 13.0±1.1 | 0.070 |
Liver Triglycerides (mg*g of liver-1) | 4/4 | 6.0±0.2 | 8.8±0.9 | 0.035 |
Mean Arterial Pressure (mmHg) | 7/7 | 126.1±5 | 153.1±8 | 0.005 |
In Vivo Portal Pressure (mmHg) | 7/7 | 7.5±2.1 | 9.7±0.6 | 0.062 |
Portal Blood Flow (mL*min-1*g of liver-1) | 7/7 | 1.0±0.2 | 0.7±0.2 | 0.050 |
Hepatic Vascular Resistance (mmHg* g of liver*min* ml-1) | 7/7 | 6.9±0.9 | 15.4±2.6 | 0.027 |
Data is presented as mean ± SD. (FFA: free fatty acids).