Table 1. Effect of aspartame consumption on weight gain, adiposity, glucose homeostasis and lipid profile.
| Male | Female | |||||||||||
| Control | Aspartame | Control | Aspartame | |||||||||
| Body Weight (6 weeks) | 17.6 | ± | 0.13 | 17.22 | ± | 0.35 | 14.31§§ | ± | 0.17 | 14.34§§ | ± | 0.22 |
| Body Weight (17 weeks) | 24.02 | ± | 0.48 | 24.96 | ± | 0.4 | 18.91§§ | ± | 0.21 | 19.42§§ | ± | 0.27 |
| % Weight Gain | 36.42 | ± | 2.44 | 45.31* | ± | 2.71 | 32.3 | ± | 1.45 | 35.63§§ | ± | 1.5 |
| Length (cm) | 9.65 | ± | 0.08 | 10.04** | ± | 0.08 | 9.21 | ± | 0.07 | 9.52**§§ | ± | 0.06 |
| Visceral Fat (g) | 0.09 | ± | 0.02 | 0.24** | ± | 0.02 | 0.08 | ± | 0.01 | 0.13**§§ | ± | 0.01 |
| RW of Visceral Fat (g/20g BW) | 0.08 | ± | 0.01 | 0.192** | ± | 0.02 | 0.09 | ± | 0.01 | 0.13**§§ | ± | 0.01 |
| Liver Weight (g) | 0.89 | ± | 0.02 | 1.03* | ± | 0.06 | 0.76 | ± | 0.03 | 0.71§§ | ± | 0.02 |
| RW of Liver (g/20g BW) | 0.75 | ± | 0.02 | 0.82 | ± | 0.04 | 0.81 | ± | 0.03 | 0.736* | ± | 0.02 |
| Fasting Glucose (mM) | 3.1 | ± | 0.18 | 4.61** | ± | 0.43 | 2.93 | ± | 0.13 | 3.65**§ | ± | 0.17 |
| Fasting Insulin (uIU/ml) | 17.32 | ± | 2.54 | 16.67 | ± | 1.86 | 10.37§ | ± | 0.8 | 8*§§ | ± | 0.58 |
| HOMA-IR | 2.36 | ± | 0.35 | 3.19 | ± | 0.24 | 1.35§ | ± | 0.11 | 1.29§§ | ± | 0.1 |
| TG (mg/dL) | 104.17 | ± | 7.42 | 107.41 | ± | 5.88 | 123.25 | ± | 6.67 | 98.24* | ± | 6.32 |
| T-CHOL (mg/dL) | 121.5 | ± | 1.08 | 121.08 | ± | 1.4 | 121.92 | ± | 0.91 | 122 | ± | 0.46 |
| HDL-C (mg/dL) | 77.13 | ± | 3.55 | 63.25** | ± | 3.04 | 54.47§§ | ± | 2.73 | 41.45**§§ | ± | 2.23 |
| LDL (mg/dL) | 23.54 | ± | 3.10 | 36.34* | ± | 3.42 | 42.80 | ± | 2.63 | 60.89**§§ | ± | 2.41 |
BW, Body Weight; RW, Relative weight.
Data presented are means ± SEM, n = 12 per group. P-value <.05 and < 0.01 based on t-test comparisons of diet groups within sexes are indicated by * and **; and comparison of sexes by § and §§ respectively.