Table 1. Startle response.
Day | WT | Nrg1 TM HET | ||||||
Vehicle | CBD 1 | CBD 50 | CBD 100 | Vehicle | CBD 1 | CBD 50 | CBD 100 | |
1 | 48.8±4.9 | 56.0±7.7 | 51.8±4.9 | 81.2±6.8 ## | 46.8±6.0 | 37.3±3.2 | 57.2±10.0 | 78.8±8.2 ## |
21 | 44.4±3.5 | 50.9±4.9 | 56.2±5.3 | 59.7±6.3 | 50.3±7.0 | 43.5±4.4 | 45.4±5.8 | 59.0±7.9 |
WH | 52.8±4.1 | 54.2±5.3 | 50.8±5.4 | 46.3±3.9 | 47.2±7.3 | 39.7±3.6 * | 34.9±4.7 * | 40.4±5.9 |
Acute CBD (100 mg/kg) increases startle response [arbitrary units] to a 120 dB acoustic stimulus. Data represent means (± S.E.M.). Significant one-way ANOVA (split by corresponding factor) results are shown:
P<0.05 (vs. WT receiving corresponding treatment);
P<0.01 (vs. vehicle of corresponding genotype).