Table 2. Social interaction.
Parameter | WT | Nrg1 TM HET | ||||||
Vehicle | CBD 1 | CBD 50 | CBD 100 | Vehicle | CBD 1 | CBD 50 | CBD 100 | |
Nosing [n] | 40.7±2.4 | 41.5±2.4 | 42.4±3.2 | 46.1±2.5 | 43.4±2.9 | 50.2±3.7 * | 52.0±3.5 * | 48.2±3.2 |
Nosing duration [s] | 46.6±2.0 | 44.9±4.1 | 47.8±3.2 | 55.2±5.1 | 41.5±2.7 | 45.3±3.1 | 62.4±6.0 ## | 51.6±5.8 |
Anogenital sniffing [n] | 21.1±1.7 | 18.5±2.2 | 21.5±2.3 | 25.2±2.8 | 17.8±2.0 | 21.3±2.8 | 29.4±2.6 ## | 26.2±3.4 |
Anogenital sniffing duration [s] | 20.3±2.1 | 19.0±2.8 | 23.4±3.3 | 27.2±3.1 | 14.4±1.9 | 19.3±3.1 | 29.9±3.6 ## | 23.3±1.9 ## |
Total social interaction duration [s] | 74.4±5.5 | 67.1±6.4 | 76.7±6.8 | 86.6±7.6 | 60.2±4.1 | 67.0±6.1 | 98.8±10.3 ## | 84.8±10.3 |
Frequency and duration of nosing and anogenital sniffing with a standard opponent A/JArc mouse after injection with CBD (1, 50 or 100 mg/kg). Data represent means (± S.E.M.). Significant one-way ANOVA (split by corresponding factor) results are shown:
P<0.05 (vs. WT receiving corresponding treatment);
P<0.01 (vs. vehicle of corresponding genotype).