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. 2012 Apr 3;7(4):e34204. doi: 10.1371/journal.pone.0034204

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Sali et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Effect of treatments on cardiac function and fibrosis. (A) Ejection fraction (%) and (B) shortening fraction (%) were assessed by echocardiography in mice who received no treatment (N = 30, 21) or GC treatment (N = 25, 19) for 100 or 180 days, respectively. (C) Sirius Red staining of formalin-fixed heart sections was used to estimate collagen content. mdx mice received no treatment (N = 12, 13) or GC treatment (N = 11, 14) for 100 or 180 days, respectively. Error bars indicate mean +/- SEM. **p = <0.01 and ***p = <0.001.