Fig. 7.

Stra8 is a modifier of teratoma susceptibility. (A,B) Photomicrographs of a Hematoxylin and Eosin stained 6-week-old 129-Stra8^KO/KO testis lacking meiotic germ cells (A), and 6-week-old 129-Stra8^KO/KO testis with a teratoma consisting of neuronal, muscle, secretory epithelial, bone marrow, bone, and cartilage (B). (C) χ2 analysis of the teratoma survey of 129 wild-type and 129-Stra8^KO/+ (control) and 129-Stra8^KO/KO (experimental) siblings reveals that Stra8 deficiency reduces teratoma incidence by 88%. Scale bars: 100 μm.