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. 2012 May 1;139(9):1577–1586. doi: 10.1242/dev.076851

Fig. 8.

Fig. 8.

Teratoma-susceptible germ cells initiate but do not complete prophase I of meiosis. Chromosome spreads from E14.5 and E16.5 gonads were immunostained for DAPI and SYCP3 and imaged by confocal microscopy. (A) An E14.5 male, FVB germ cell nucleus with pre-lepotene, nucleolar localization of Sycp3. (B) At E14.5 and E16.5, some male M19 germ cell nuclei have a leptotene to early zygotene SYCP3 distribution with no evidence of chromosome pairing or synapsis. (C) An SYCP3-immunostained, E16.5 M19 female germ cell in the pachytene stage of meiotic prophase. Scale bars: 5 μm.