Table 1. Reduction in Lmo4 levels does not affect anxiety-like behavior.
Behavior | Parameter measured | WT | Lmo4gt/+ | shLmo4 | shScr |
Elevated Plus Maze | % Open Arm Entries | 41.14±3.03 | 40.41±2.23 | 36.54±3.5 | 37.66±3.76 |
% Time in Open Arms | 19.42±3.81 | 22.72±3.43 | |||
29.84±3.98 | 27.62±4.87 | ||||
Light/Dark Box | % Time in Lit Compartment | 35.44±1.68 | 38.63±6.62 | 29.7±4.18 | 29.5±3.6 |
Open Field | % Time Spent in Center | 16.77±1.85 | 12.74±1.44 | 9.92±1.47 | 10.56±1.48 |
Distance Traveled (cm) | 1028.2±61.81 | 817.91±90.89 | 1118.39±86.65 | 1031.17±68.48 |
The effects of global (Lmo4gt/+) or adult-and brain region-specific knockdown of Lmo4 in the BLC on anxiety-like behavior was examined. Mice were subjected to the elevated plus maze, light/dark box, or the open field test. Mean values ± SEM are depicted. N = 11–12 (WT) and 9–11 (Lmo4gt/+) mice and n = 9–10 for shLmo4 and 10 for ShScr injected mice.