Figure 2.

In vivo orthotopic and ectopic implantation of anatomically shaped tooth scaffolds. (A) In vivo implantation of human mandibular molar scaffold into rat’s dorsum constitutes an ectopic model for tooth regeneration. (B) Harvest of human molar scaffold showing integration and tissue ingrowth. (C) Extraction of the right rat mandibular central incisor. (D) The extracted rat mandibular central incisor. (E) The fabricated rat mandibular central incisor scaffold. (F) Harvest of in vivo-implanted rat mandibular central incisor scaffold orthotopically in the extraction socket showing integration of the implanted scaffold. Scale: 5 mm.