Figure 5.
G-quadruplexes are specifically found in the majority of metazoan Oris, in association with the OGRE motif. (A) Definition of the G-quadruplexes (G4) that were used in this study. (B) Venn diagram showing the association of OGRE occurrences and G4 in mouse chromosome 11. (C) Predicted G4 formed by an Oris-associated OGRE occurrence. (D) The association between Oris and G4 are illustrated with a Venn diagram. (E) Repartition of Oris from mouse ES cells based on to the presence of OGRE s and/or G4. (F) The nascent Strands (NS) enrichment around G4 occurrences is shown. A strong NS peak is found ∼260 nucleotides downstream of the G4. A small NS peak is also observed upstream similarly to what described for OGRE s (see Fig. 2A and B).