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. 2012 Feb 15;11(4):695–705. doi: 10.4161/cc.11.4.19120

Figure 6.

Figure 6

Top panel: Ki-67 staining shown in the nucleus of insulin and glucagon positive cells in the pancreas of diabetic rat one week after UTMD with cyclin D2/CDK4/GLP1 (animals euthanized one week after UTMD), x600 magnification; the graph is a plot of the percentage of Ki-67 positive cells in total β cells for all experimental groups. #p > 0.05 vs. Normal group and STZ group; **p < 0.0001 vs. normal and STZ groups. n = 6 animals, Error bars represent mean ± SEM, N values are numbers of pancreas analyzed for each group. Third panel: Insulin and glucagon positive cells are self-duplicating in the pancreas of diabetic rat one week after UTMD with cyclin D2/CDK4/GLP-1 genes (animals euthanized one week after UTMD). Histone H3 (phospho-Ser10) (a mitosis marker) is clearly seen in the nucleus of insulin and glucagon positive cells, x600 magnification. Bottom panel is a plot of the percentage of Histone H3 positive cells in total β cells for all experimental groups. #p > 0.05 vs. Normal group and STZ group; **p < 0.0001 vs. normal and STZ groups. n = 6 animals, Error bars represent mean ± SEM, N values are numbers of pancreas analyzed for each group.