Figure 3.

P-domain width adapts to mechanical perturbations to maintain treadmill. Numerical calculation of the P-domain width, L (upper), polymerization speed, v_g (lower, solid line), and retrograde flow speed, v_r (lower, dashed line), before and after blebbistatin treatment (at time t = 0), illustrating the transition to a new steady-state treadmill. Using calibrated values of the system parameters, the model reproduces experimental measurements of v_r and L after blebbistatin treatment. Note that the steady-state values of L and v_r are independent of the polymerization load-velocity parameter ω (Fig. S2).