Figure 3.

Results of model of leading-edge actin dynamics. (A) The model includes F-actin, F, activator A, and free barbed ends, B, as functions of position along the arc-length of the membrane. (B) Reaction network diagram. Assembly of F promoted by autocatalytic activator A that generates free barbed ends. Accumulation of F inhibits A recruitment. (C) F-actin and free barbed end concentrations at a fixed point along the model membrane as a function of time. (D) Free barbed end concentration versus arc length and time. (E) Same as panel D, for F-actin. (F) Correlation coefficients versus time and with no positional offset for free barbed end autocorrelation, F-actin autocorrelation, and the cross correlation between panel B and F-actin. (G) Same as panel F, but as a function of arc length and no time offset.