Figure 1.

Schematic illustrating the relationships between each of the five parkinsonism-related covariance patterns (PRPs) and the scans from the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-lesioned and control animals (Cohorts A and B) used for pattern characterization (see text). The number of scans or hemispheres used for the derivation of each PRP (parkinsonism-related pattern) topography is marked on the flow chart from Cohorts A and B. PRP5 resulted from a whole-brain analysis of data from the animals in Cohort A. (Of note, the seven untreated hemispheres from the MPTP animals with contralateral transplants were included in Cohort B. Five of the parkinsonian monkeys in Cohort A were scanned before MPTP lesioning. These baseline images were used as control scans in Cohort B.)