Table 1. Comparison of the kinetic rate constants obtained using different compartmental models to determine Ro15-4513 binding in the brain.
| K1 | k2 | k3 | k4 | AIC | |
|---|---|---|---|---|---|
| All regions | |||||
| 2kbvf | 5.0±1.1 | 1.5±0.8 | — | — | −89.09±27.8 |
| 4kbvf | 5.4±1.1 | 1.9±1.2 | 0.42±4.43 | 0.50±7.31 | −100.76±28.8 |
| Cerebellum | |||||
| 2kbvf | 6.0±0.7 | 3.1±0.4 | — | — | −126.43±18.1 |
| 4kbvf | NA | NA | NA | NA | NA |
| Hippocampus | |||||
| 2kbvf | 4.3±0.4 | 0.77±0.13 | — | — | −63.46±13.6 |
| 4kbvf | 5.2±0.5 | 1.6±0.5 | 0.75±0.56 | 0.48±0.81 | −93.79±15.6 |
AIC, Akaike information criteria; NA, not available. All constants are expressed as mean±s.d. secconds × 10−3. Binding in the cerebellum was not successfully evaluated by a two-tissue compartment model.