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. 2012 Mar 25;2012:542092. doi: 10.1155/2012/542092

Figure 1.

Figure 1

Schematic representation of the polyomaviruses genome organization. The circular double-stranded DNA genome is length about 5kb. The early region encodes the functional proteins LTAg and small T-Antigen, while the late region encodes the structural proteins VP1-3. The genome of JCV, BKV, and SV40 also encodes a small structural protein named Agno. The noncoding control region (NCCR) contains the origin of replication and regulates the replication and transcription of both the early and late genes.