Table 1.
Performance of the skin test reagents
| Group | No. of animals | % positive (95% CI)g |
||||
|---|---|---|---|---|---|---|
| SICCT |
SITe | E/C/RVf | E/C/Rv + Rv3020cf | |||
| Standardc | Severed | |||||
| M. bovis infecteda | 16 | 87.5 (61.7–98.5) | 100 (79.4–100) | 100 (79.4–100) | 75.0 (47.7–92.7) | 87.5 (61.7–98.5) |
| Noninfected and vaccinatedb | ||||||
| Naïve controls | 7 | 0 (0–41.0) | 0 (0–41.0) | 0 (0–41.0) | 0 (0–41.0) | 0 (0–41.0) |
| BCG alone | 7 | 14.3 (0.4–57.9) | 57.1 (18.4–90.1) | 71.4 (29.1–96.3) | 0 (0–41.0) | 0 (0–41.0) |
| BCG followed by Gudair | 7 | 0 (0–41.0) | 0 (0–41.0) | 100 (59.0–100) | 0 (0–41.0) | 0 (0–41.0) |
| Gudair followed by BCG | 7 | 0 (0–41.0) | 0 (0–41.0) | 85.7 (42.1–99.6) | 0 (0–41.0) | 0 (0–41.0) |
| BCG + Gudair at same time | 6 | 0 (0–45.9) | 0 (0–41.0) | 50.0 (11.8–88.2) | 0 (0–45.9) | 0 (0–45.9) |
| Gudair alone | 7 | 0 (0–41.0) | 0 (0–41.0) | 57.1 (18.4–90.1) | 14.3 (0.4–57.9) | 14.3 (0.4–57.9) |
| Total noninfected | 41 | 2.4 (0.1–12.9) | 9.8 (2.7–23.2) | 61.0 (44.5–75.8) | 2.4 (0.1–12.9) | 2.4 (0.1–12.9) |
Values in this row represent test sensitivities.
Primary vaccination at 6 weeks of age, second vaccination (where given) at 12 weeks of age, and skin test at approximately 23 weeks of age. Values in these rows represent the percentage of false-positive test results.
Response considered positive if Δ skin thickness for PPD-B − PPD-A is >4 mm (standard OIE and United Kingdom test interpretation).
Response considered positive if Δ skin thickness for PPD-B − PPD-A is >2 mm (severe United Kingdom test interpretation).
Response considered positive if Δ skin thickness for PPD-B is ≥4 mm.
Response considered positive if Δ skin thickness is ≥1 mm. E/C/Rv denotes ESAT-6/CFP-10/Rv3615c peptide cocktail.
95% CI, 95% confidence interval.