Table 3.
MICA-129 allele and genotype frequencies among T1D juvenile, LADA, and control groups
| MICA-129 polymorphism | Distribution analysis by groupa |
||||||||
|---|---|---|---|---|---|---|---|---|---|
| T1D |
LADA |
Frequency in the controls (no. [%]) | |||||||
| Frequency (no. [%]) | Pc | χ2 | OR (95% CI) | Frequency (no. [%]) | Pc | χ2 | OR (95% CI) | ||
| Alleles | |||||||||
| MICA-129 Val | 47 (78.33) | 0.034 | 2.8 | 1.92 (0.916–4.214) | 71 (82.56) | 2.2 × 10−3 | 7.152 | 2.51 (1.266–5.18) | 98 (65.33) |
| MICA-129 Met | 13 (21.67) | 0.034 | 2.8 | 0.52 (0.237–1.092) | 15 (17.44) | 2.2 × 10−3 | 7.152 | 0.40 (0.193–0.79) | 52 (34.67) |
| Genotypes | |||||||||
| MICA-129 Val/Val | 18 (60.00) | 0.043 | 2.297 | 2.13 (0.827–5.571) | 29 (67.44) | 3.3 × 10−3 | 6.44 | 2.94 (1.254–7.02) | 31 (41.33) |
| MICA-129 Met/Val | 11 (36.67) | 0.151 | 0.7 | 0.63 (0.236–1.619) | 13 (30.23) | 0.031 | 2.859 | 0.47 (0.194–1.106 | 36 (48.00) |
| MICA-129 Met/Met | 1 (3.33) | 0.153 | 0.68 | 0.29 (0.006–2.345) | 1 (2.33) | 0.062 | 1.645 | 0.20 (0.004–1.594) | 8 (10.67) |
a
Groups consist of 30 T1D and 43 LADA patients and 75 controls. OR, odds ratio; 95% CI, 95% confidence interval. Boldface indicates significant differences in the allele and genotype frequencies between each of the three groups (Pc < 0.05).