Table 4.
MICA alleles and HLA-DR-DQ haplotypes in relation to T1D juvenile, LADA, and control groups
| HLA-DR-DQ haplotype | MICA-129 genotype | Distribution analysis by groupa |
||||||
|---|---|---|---|---|---|---|---|---|
| LADA (n = 43) |
Juveniles (n = 30) |
Frequency (no. [%]) in the controls (n = 75) | ||||||
| Frequency (no. [%]) | Pc | OR (95% CI) | Frequency (no. [%]) | Pc | OR (95% CI) | |||
| DR3 DQ2 | Met/Met | 1 (2.33) | 0.303 | 1.76 (0.022–140.14) | 1 (3.33) | 0.201 | 2.55 (0.031–202.950) | 1 (1.33) |
| Met/Val | 10 (23.26) | 0.118 | 1.76 (0.600–5.09) | 11 (36.67) | 0.007 | 3.37 (1.117–10.013) | 11 (14.67) | |
| Val/Val | 21 (48.84) | 9.1 × 10−7 | 9.27 (3.194–28.84) | 16 (53.33) | 1.3 × 10−6 | 11 (3.448–37.291) | 7 (9.33) | |
| DR4 DQ8 | Met/Met | 1 (2.33) | 0.303 | 0.00 (0.015–18.30) | 0 (0) | 0.0 | 0(0.0) | |
| Met/Val | 5 (11.63) | 0.167 | 1.83 (0.395–8.51) | 5 (16.67) | 0.057 | 2.8 (0.584–13.155) | 5 (6.67) | |
| Val/Val | 15 (34.88) | 2.0 × 10−5 | 9.51 (2.665–41.89) | 9 (30.00) | 5.2 × 10−4 | 7.61 (1.848–36.4) | 4 (5.33) | |
| DR15/DQ6 | Met/Met | 0 (0.0) | 0.156 | 0.0 (0.000–72.56) | 0 (0.0) | 0.249 | 0.0 (0.000–6.089) | 3 (4) |
| Met/Val | 1 (2.33) | 0.041 | 0.17 (0.004–1.35) | 0 (0.0) | 0.027 | 0.0 (0.000–1.207) | 9 (12) | |
| Val/Val | 6 (13.95) | 0.105 | 0.51 (0.153–1.52) | 1 (3.33) | 5.4 × 10−3 | 0.11 (0.003–0.772) | 18 (24) | |
| Other | Met/Met | 0 (0) | 0.097 | 0.0 (0.000–1.54) | 0 (0.0) | 0.174 | 0.0 (0.000–3.795) | 4 (5.33) |
| Met/Val | 6 (13.95) | 0.341 | 0.77 (0.222–2.42) | 1 (3.45) | 0.032 | 0.16 (0.004–1.210) | 13 (17.33) | |
| Val/Val | 10 (23.26) | 0.021 | 2.94 (0.908–9.90) | 4 (13.33) | 0.239 | 1.49 (0.294–6.450) | 7(9.33) | |
a
OR, odds ratio; CI, confidence interval; Pc, corrected P value. Boldface indicates significant differences in the allele and genotype frequencies between each of the three groups (Pc < 0.05).