Table 2.
Simulated AUCτ and the probability of achieving an AUCτ/MIC ratio of ≥219 in subjects with various degrees of renal function
| Parameter | CLCR (ml/min) |
||
|---|---|---|---|
| <30a | 30–50b | >50c | |
| AUCτ (mean ± SD, mg · h/liter) | 1,058 ± 316 | 762 ± 238 | 776 ± 264 |
| AUCτ range (minimum, maximum; mg · h/liter) | 466, 2,071 | 318, 1,974 | 203, 2,820 |
| Probability (%) of achieving AUCτ/MIC ratio ≥ 219 at MIC | |||
| 0.5 mg/liter | 100 | 100 | 100 |
| 1 mg/liter | 100 | 100 | 100 |
| 2 mg/liter | 98.6 | 95.0 | 93.8 |
a
Based on 140 simulated profiles.
b
Based on 480 simulated profiles.
c
Based on 9,640 simulated profiles.