Fig 1.

Structure of pMR0211. (A) Alignment of pAR060302 (4) and pNDM-HK (12) with pMR0211 showing areas of homology between all three plasmids. White shading (on pAR060302 and pNDM-HK only) indicates areas with no homology to pMR0211. Red shading indicates regions with homology to pAR060302. Green shading indicates regions with homology to pNDM-HK. Blue shading (on pMR0211 only) indicates regions with no orthologs in pAR060302 and pNDM-HK. Solid lines connecting the plasmids indicate insertion and deletion events in pMR0211 compared to the other plasmids. The sizes of the respective plasmids are indicated at the 3′ terminus. (B) Circular representation of plasmid pMR0211. Colored shading represents genes and regions with homology to pAR060302, pNDM-Hk, and pMR0211 as described above. The repA gene and putative antibiotic resistance genes with their respective orientations are indicated in the outermost region by block arrows with the same color scheme. White block arrows indicate the orientation and position of putative insertion sequence elements and transposons.