Table 4.
Redox compounda | Disc load (μmol) | Inhibition zoneb (mm) for M. bovis BCG strains |
|
---|---|---|---|
Wild type | KOTapc | ||
Hydrogen peroxide | 80 | 15 | 18 |
40 | 13 | 14 | |
Plumbagin | 0.01 | 26 | 30 |
Diamide | 20 | 0 | 18 |
Dimethyl sulfoxide, which was used as the solvent for some of these compounds, had no effect on the growth of either strain (data not shown).
Zones of inhibition were recorded after 21 days at 37°C.
KOTap is M. bovis BCG with the tapTB gene inactivated.