Fig 6.

Homologues (black arrows) of VanJ are widespread in Streptomyces strains. Above the line, the genetic context of putative orthologues that show high sequence homology (70 to 80% amino acid identity) to VanJ and are located adjacent to close homologues of other van resistance genes (gray arrows) is shown. The locations and orientations of conserved van promoter sequences are marked with arrows. Below the line, the context of the other VanJ homologues present in S. coelicolor and S. avermitilis that exhibit a lower sequence identity (50 to 60%), as discussed in the text, is shown.