Table 1.

Summary of amprenavir concentrations and sampling by fosamprenavir dosing schedule

Parameter	Amprenavir concn (ng/ml) or IQR		CSF-to-plasma ratio or IQR	CSF-to-IC50 ratio or IQR
	CSF	Plasma (overall)
Regimen
FPV 700 mg BID, with RTV	60	62	60	60
FPV 1,400 mg once a day, with RTV	33	34	33	33
FPV 1,400 mg BID, no RTV	22	23	22	22
Total	115	119	115	115
Median
FPV 700 mg BID, with RTV	31.6	2,230	0.014	4.2
FPV 1,400 mg once a day, with RTV	20.5	2,460	0.010	3.7
FPV 1,400 mg BID, no RTV	23.4	1282	0.018	5.6
Overall	24.8	2,261	0.012	4.4
IQR
FPV 700 mg BID, with RTV	18.3–51	1,459–3,559	0.009–0.018	1.9–7.4
FPV 1,400 mg once a day, with RTV	14.9–35.2	1,556–3,185	0.007–0.012	2.7–6.3
FPV 1,400 mg BID, no RTV	10.7–41.5	718–3,108	0.008–0.031	3.3–9.1
Overall	16.2–44.0	1,397–3,353	0.008–0.018	2.9–7.9