Table 1.

Meropenem regimens, concentrations, and pharmacodynamics during therapy^a

Day of therapy	MEM dose	Time of sampling	MEM concn (mg/liter)	MIC (mg/liter)	% T > 4× MIC
1	1 g q8h
2	1 g q8h	2 h	12.3	2	37
		8 h	<2.0
5	1 g q8h	2 h	13.4	2	39
		8 h	<2.0
9	2 g EI q8h	3 h	17	4	39
		8 h	3
15	3 g EI q6h	3 h	43	8	51
		6 h	19

^aMEM, meropenem; q8h and q6h, every 8 h and 6 h; EI, extended infusion (over 3-h period); 2 h, 3 h, 6 h, and 8 h, 2, 3, 6, and 8 h after the onset of MEM administration; T > 4× MIC, time above 4 times the MIC.