Table 1.
Influence of NCT at different concentrations on coagulation parameters in whole human blooda
| Concn of NCTb (mM) | PT (%) | aPTT (s) | TT (s) | Fibrinogen concn (mg/dl) |
|---|---|---|---|---|
| 55 (1) | < limit | > limit | > limit | Not detectable |
| 27.5 (0.5) | < limit | > limit | > limit | Not detectable |
| 13.8 (0.25) | < limit | > limit | 101.8 | Not detectable |
| 5.5 (0.1) | < limit | 371.4 | 92.2 | Not detectable |
| 2.75 (0.05) | 33.4 | 71.3 | 48.8 | Not detectable |
| 1.38 (0.025) | 70.6 | 37.7 | 26.6 | 199.4 |
| 0.55 (0.01) | 91.4 | 30.6 | 19.5 | 281.4 |
| 0 NCT, salinec | 89.3 | 29.9 | 19.5 | 289.5 |
| 0 NCTd | 100.1 | 29.1 | 19.6 | 388.3 |
a
Results are from a single pilot experiment. PT, prothrombin time; aPTT, activated partial thromboplastin time; TT, thrombin time. > limit/< limit, value exceeded/went below the test limit.
b
NCT was dissolved in saline and 10-fold diluted in whole human citrate blood (0.2 ml plus 1.8 ml). Data in parentheses are percentages.
c
Blood (1.8 ml) plus 0.2 ml physiological saline solution.
d
Citrate blood without any additives.