Fig 6.

DksA protects Salmonella from nitrogen oxides produced by a functional iNOS hemoprotein in a murine model of salmonellosis. (A) C57BL/6 mice were inoculated intraperitoneally with ∼200 to 400 CFU of either the wild-type (WT), ΔdksA, or ΔdksA mutant Salmonella strain complemented with a wild-type dksA allele (cDksA) or with a dksA C114S-, C117S-, C135S-, or C138S-expressing variant. (B) Congenic iNOS-deficient mice were inoculated intraperitoneally with ∼400 CFU of either the WT or ΔdksA mutant Salmonella strain. The fractions of mice surviving the experimental Salmonella infections were evaluated over time. Data represent 10 mice per group and were obtained from two separate experiments.