Figure 3.

Phenotype of the effector cells. Normal BALB/c mice or mice depleted of CD4⁺ or CD8⁺ cells (after two i.v. injections of mAb within 10 days) were injected s.c. with 10⁴ MOPC-315 cells. After tumor-cell challenge (11–13 days), mice were treated with Epo. Tumor regression was observed in 50% of mice in the Epo-treated control group. In contrast, 90–100% tumor growth was observed in Epo-treated mice depleted of CD4⁺ or CD8⁺ cells. Square, normal + Epo; circle, anti-CD8 mAb + Epo; triangle, anti-CD4 mAb + Epo.