Table 1.
Estimates of evolutionary divergence between amino acid sequences of the full fusion protein of the Venezuelan isolate and those of commercial vaccines and reference strains of different genotypesa
| Strain | % amino acid substitutions0 compared to: |
|
|---|---|---|
| 293927 LaSota vaccine | Venezuela 2008 | |
| JN800306 Venezuela 2008 | 12.4 | 0.0 |
| 148534707 Goose/China/2006 | 12.7 | 1.4 |
| 146359113 Mallard/China/2006 | 11.8 | 1.8 |
| 268043733 Goose/China/2008 | 12.8 | 1.8 |
| 28933797 Goose/China/2007 | 13.3 | 1.8 |
| 110225441 Goose/NA1/China/2006 | 12.0 | 1.9 |
| 18042226 ZJ1/Goose/China/2007 | 13.5 | 1.9 |
| 109290367 Chicken/China/2003 | 12.1 | 2.3 |
| 109290353 Chicken/China/2002 | 12.8 | 2.3 |
| 45511225 Chicken/USA/1972 | 10.1 | 4.3 |
| 217323230 Pigeon (MD)/USA/1984 | 10.9 | 5.2 |
| 269838473 Pigeon/UK/2007 | 10.9 | 5.2 |
| Chicken/Peru/2008 | 12.6 | 5.8 |
| 258547239 Pigeon (AV324)/Ireland/1996 | 12.1 | 6.6 |
| 262217133 Chicken/China/QH1/1979 | 10.4 | 6.6 |
| 53636432 Chicken/Hertz | 8.6 | 6.6 |
| 161110504 Chicken (SRZ)/China/2003 | 7.3 | 7.0 |
| 45511239 Mixed (Largo, MD)/USA/1971 | 12.4 | 8.0 |
| 253317778 Cormorant/USA/1997 | 12.9 | 8.4 |
| 61393396 Chicken/Australia/1992 | 8.5 | 8.7 |
| 33348851 Chicken/China | 8.2 | 8.8 |
| 293933 Chicken/Australia/1932 | 9.2 | 8.8 |
| 7229463 Chicken (QV4)/Australia/1967 | 7.4 | 9.0 |
| 253317820 Cormorant/USA/1992 | 12.3 | 9.3 |
| 11527326 B1 vaccine | 0.9 | 12.2 |
| 293927 LaSota vaccine | 0.0 | 12.4 |
a
The percentages of amino acid substitutions between sequences are shown. The numbers used to identify the viruses represent the GenBank GenInfo (GI) sequence identification numbers. Analyses were conducted using the JTT matrix-based model as implemented in MEGA5 (26). The rate variation among sites was modeled with a gamma distribution (shape parameter = 1). All positions containing gaps and missing data were eliminated. There were a total of 551 positions in the final data set.