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. 2012 Apr;50(4):1397–1405. doi: 10.1128/JCM.06533-11

Table 1.

Major and minimal epitopes of HRP-specific MAbs, occurrence in P. falciparum field isolates, and heat stability

MAb Major epitope(s) Minimum epitopeb
Reactivity before and after incubation at 37°Cc
Epitope Prevalence in isolates tested (%) Avg frequency Day 0 30 days 90 days
3A4a DAHHAHHA AHHAHHA 448/448 (100) 15 +++++ +++
2G12-1C12a DAHHAADAHH DAHHAADAHH 448/448 (100) 10 +++++ +++++
DAHHVADAHH
1E1-A9a YAHHAHHA AHHAHHV 445/448 (99.3) 3 +++++ +++
DAHHAHHV
4A5a Conformational Conformational NA NA +++++ ++++
A6-4 HATDAHHAAD HATDAHH 448/448 (100) 5 +++++ ++
HATDAHHAAA
C1-13 AHHAADAHHA AHHAADAHH 448/448 (100) 18 +++++ +++++ +++
N7 DAHHAADAHHA DAHHAADAHHA 448/448 (100) 10 +++++ +++
PTL-3 DAHHAHHA YAHHAHHA 439/448 (97.9) 3 +++++ +++++ +++
YAHHAHHA
S2-5 AHHAADAHH AHHASDAHHA 367/448 (82) 1 +++++
AHHASDAHH
TC-10 TDAHHAADAHHAADA TDAHHAADAHHAADA 327/448 (72.9) 1 ND ND ND
C2-3 AHHAADAHH HAHHAHHAADAHH 123/448 (27.4) 0 +++++ ++
Genway AAYAHHAHHAAY AYAHHAHHAAY 3/448 (0.01) 0 ND ND ND
a

Epitope mapping previously published (8).

b

NA, not applicable.

c

Signal strength was graded on an arbitrary scale from +++++ (maximum) to + (just visible) to − (absent). ND, not determined.