Fig 6.

Contribution of various predicted domains to CASZ1b transcriptional activity. (A) Schematic of full-length CASZ1b showing the locations of the predicted peroxisome-targeting sequence (PTS2), proline-rich domain (PRO), and ATP/GTP-binding motif (ATP). (B) Activation of the TH-luciferase construct 24 h after transfection by ΔPTS2, ΔPRO, and ΔATP CASZ1b variants (*, P < 0.001). (C) Western blot showing that steady-state protein levels are comparable to those of WT CASZ1b 24 h after transfection.