Fig 4.

Obesity and P465L PPARγ mutation modify the architecture of the lipid droplet protein pool. Shown is lipid droplet protein expression analysis of P465L mutant adipocytes from lean and obese mice versus mature adipocytes isolated from 12- to 16-week-old wt counterparts. The data represent means ± SE for 8 to 12 animals per group. Fold changes were established using the wt as 100. Differences in expression between groups were assessed by ANOVA (G, effect of P465L mutation; OB, effect of obesity; G, OB, interactive effect) and the Student t test. *, P465L versus wt or P465L/ob/ob versus ob/ob; °, wt versus ob/ob or P465L versus P465L/ob/ob. The level of probability was set at a P value of <0.05.