Fig 6.

(A to C) prkaca, d-akap1, and lipid droplet protein mRNA expression in adipose tissue from lean versus morbidly obese low-insulin-resistance and morbidly obese high-insulin-resistance subjects. (B and C) Adipocytes from obese subjects after acute exposure to rosiglitazone. (A) d-akap1 and prkaca mRNA expression is decreased in human obesity. (B)Rosiglitazone (Rosi) increases expression levels of d-akap1 and prkaca. *, differentiated (Diff) adipocytes. (C) Obesity severely affects the lipid droplet protein pool in human subjects. The data represent means ± SE. Differences in expression between groups were assessed by ANOVA and the Student t test. ★, P < 0.05 versus Diff; ★★, P < 0.005 versus Diff.