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. 2012 Apr;32(8):1483–1495. doi: 10.1128/MCB.05245-11

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Fig 4 — Defective ERα- and PRβ-driven transcriptional activation in Med1^+/− Med24^+/− MEFs. (A) ERα-driven transcriptional activation is mildly attenuated in Med1^−/− Med24^+/+ MEFs and profoundly attenuated in Med1^+/− Med24^+/− MEFs. Values (means ± SD from a representative experiment performed in triplicate) are plotted as fold increase against the value of Med1^+/+ Med24^+/+ MEFs without ligand (A to C). The ligands used are 10⁻⁸ M E2, 10⁻⁷ M progesterone, and 10⁻⁷ M 1,25-dihydroxyvitamin D₃ [1,25(OH)₂D₃] (A to C). (B) PRβ-driven transcriptional activation is attenuated profoundly in Med1^+/− Med24^+/− MEFs. (C) Gal-VDR-driven transcription is attenuated in Med1^−/− Med24^+/+ MEFs but not affected in Med1^+/− Med24^+/− MEFs. (D) Gal-VP16-driven transcription is not affected in Med1^+/− Med24^+/− MEFs. Values (means ± SD from a representative experiment performed in triplicate) are plotted as fold increase against the value of Med1^+/+ Med24^+/+ MEFs without Gal4-VP16.