Table 3.
Patient no. | WHO diagnosis | Cytogenetics | Baseline WBC* | Baseline blast count | Response | Cytogenetic response? | Day of therapy at CR/CRi | Duration of CR/Cri, mo | PFS, mo | OS, mo |
---|---|---|---|---|---|---|---|---|---|---|
17 | Therapy-related AML | Complex | 600 | 0 | CRc | Yes | C1D28 | 1 | 2 | 5 |
21 | AML with MDS-related features | Complex | 1200 | 20 | CRi | No | C2 | 6 | 8 | 11 |
23 | AML with MDS-related features† | Normal | 1600 | 0 | CR | NA | C1D28 | 6 | 7 | 16 |
25 | AML without maturation | t(2;14) | 1600 | 60 | CRc | Yes | C2 | 13 | 15 | 16 |
26 | Monoblastic AML (M5a) | Normal | 1700 | 0 | CRi | NA | C1D15 | 2 | 2 | 6 |
32 | AML with maturation | Normal | 4300 | 220 | CR | NA | C2 | ≥ 15 | ≥ 17 | ≥ 17 |
34 | AML with minimal differentiation | t(1;3) | 4200 | 710 | CRi | Yes | C1D15 | ≥ 17 | ≥ 17 | ≥ 17 |
39 | Monocytic AML (M5b) | MLL abnormal | 1600 | 0 | CRc | Yes | C1D28 | ≥ 15 | ≥ 16 | ≥ 16 |
44 | AML with MDS-related features | Normal | 2800 | 30 | CRi | NA | C1D28 | 1 | 2 | 3 |
45 | AML with maturation | Normal | 1300 | 0 | CR | NA | C2 | ≥ 13 | ≥ 14 | ≥ 14 |
MLL indicates mixed lineage leukemia; C, cycle; D, day; and NA, not applicable.
WBC and blast count are shown per microliter of PB.
Patient 23 received 7 cycles of azacitidine for MDS ending 1 year before enrollment in the current study.