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Protection after i.m. or s.c. (SQ) immunization of mice. BALB/c mice were mock immunized or immunized i.m. or s.c. with 5 × 105 PFU gE2-del virus and were challenged IVAG with 250 PFU HSV-2 MS. (A) Survival kinetics. (B) Vaginal disease scores. (C) Vaginal viral titers. Each group had 5 animals. Disease scores are plotted only for surviving animals. Results in panels B and C represent means ± SEM.
