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Protection after one or two i.m. immunizations with gE2-del virus in mice. BALB/c mice were immunized once or twice at 3-week intervals and challenged IVAG with 5 × 104 PFU HSV-2 MS. (A) Survival kinetics. (B) Vaginal disease scores. (C) Vaginal viral titers. Each group had 5 animals. Results in panels B and C represent geometric means ± SEM. (D) Photographs taken on day 7 postinfection are representative of mice in each group. Scores are indicated beneath the photographs.
