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Therapeutic treatment of HSV-2-infected guinea pigs with gE2-del virus. (A) Schedule of initial vaginal infection, therapeutic immunizations, and bleeds. (B) gD2 antibody responses in mock-immunized and gE2-del virus-immunized guinea pigs. Results represent mean titers ± SEM. (C) Seven weeks of cumulative lesion recurrences per animal are plotted, beginning 1 week after the first immunization.
