Table 1.
LD50 of gE2-del and parental virus strains in mice
| Virus | LD50 (PFU) |
||||||
|---|---|---|---|---|---|---|---|
| Intramuscular |
Intravenous |
Intravaginal |
Intracerebral |
||||
| BALB/c | SCID | BALB/c | SCID | BALB/c | SCID | BALB/c | |
| gE2-del | >5 × 106 | >5 × 106 | >5 × 106 | >5 × 106 | >5 × 105a | >5 × 106 | 1.3 × 106 |
| HSV-2 2.12 | 1.6 × 104 | 5 × 104b | 1 × 104 | <5 × 103 | 3.4 × 101 | <5 × 101 | <5 × 100 |
| Difference in LD50 between viruses | >3 × 102 | >102 | >5 × 102 | >103 | >104 | >105 | >3 × 105 |
a
A titer of 5 × 105 PFU was the highest titer tested after intravaginal infection in BALB/c mice.
b
The result shown represents 35 SCID mice infected with HSV-2 2.12 over the range of 5 × 101 to 5 × 105 PFU, including 10 mice each at 5 × 103 and 5 × 104 PFU.