Fig 4.

Intensities of antibody responses against four immunodominant HSV-1 antigens from symptomatic and asymptomatic patients. The average intensity of recognition of RTS expressing US4, US11, UL30, and UL42 proteins by serum antibodies from HSV-seropositive symptomatic (n = 10) and asymptomatic patients (n = 10) was determined by an ELISA. The optical density (OD) at 450 nm determined by an ELISA is shown for each serum sample. The P value was calculated by t tests. Note the difference in serum antibody responses induced by US11 and UL30 in asymptomatic versus symptomatic patients. The antibody recognition of four antigens (US4, US11, UL30, and UL42) was different by >2-fold between serum samples from symptomatic and asymptomatic subjects.