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Phenotypes of representative plaque-purified progeny from cells electroporated with chimeric B142–173/M RNA. (A) Plaque appearances after culturing for 60 h on L2 cells. Isolated small plaques (S1 to S3 out of 6 total) and large plaques (L1 and L2 out of 11 total) were serially passaged 10 times on DBT cells. (B) Growth kinetics for three isolated small plaques (hatched lines) and two isolated large plaques (solid lines) following their selection at viral passages 1, 6, and 10.
