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Reverse genetics-derived VRPRVF are morphologically indistinguishable from wild-type RVFV. (A) Schematic of the Rift Valley fever virus (RVFV) genome (top) and the reverse genetics system as used for virus replicon particle (VRPRVF) production (bottom). vc, viral complementary. (B) Negative-stain electron microscopy images demonstrating the morphological similarity of RVFV particles (left) and VRPRVF particles (right).
