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VRPRVF immunization is protective as early as 24 h postimmunization. Survival curves from early protection studies. C57BL/6 mice were immunized with VRPRVF or nr-VRPRVF and challenged with virulent virus (A) 24 h, (B) 48 h, or (C) 72 h later. Survival curves were significantly different at 48 h (P = 0.008) and 72 h (P = 0.025).
