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Genomic map of mutated genes. (a) Prototypic arrangement of the HSV-1 genome with the unique long (UL) and unique short (US) regions flanked by the terminal repeat (TR) and internal repeat (IR; L, long; S, short) regions; (b) expanded genomic regions of the UL10, UL11, UL20, US6, and US8 ORFs; (c) effect of ATG mutagenesis on gM, gE, UL11, and UL20 gene expression (hatched regions), as well truncation of gD after gDΔct mutagenesis (hatched gD region).
