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. 2012 Jan 17;287(11):8495–8506. doi: 10.1074/jbc.M111.323915

FIGURE 8.

FIGURE 8.

Enzymatic catalysis of glutamate prevents acute and prolonged effects of CaMKII inhibition. A, glutamate concentration (mean ± S.D., n = 4–8) in neuronal media following incubation with 10 μm tat-CN21 for 24 h with and without co-application of GPT/pyruvate, GPT alone, or boiled GPT/pyruvate. *, p < 0.05 compared with control; #, p < 0.05 compared with tat-CN21/GPT/pyruvate treatment (one-way ANOVA, post hoc Dunnett's test). B, neuronal intracellular calcium levels (mean ± S.E., n = 3) following application of tat-CN21 in the presence or absence of GPT/pyruvate. Bar graph inset indicates the average integral from 0 to 1200 s (mean ± S.E., n = 3) for these treatment groups. C, neuronal death (mean ± S.E., n = 3–6) after 24 h of treatment with 10 μm tat-CN21 alone or co-application with GPT/pyruvate, GPT alone, or boiled GPT/pyruvate. *, p < 0.05 compared with control; #, p < 0.05 compared with tat-CN21/GPT/pyruvate treatment (one-way ANOVA, post hoc Dunnett's test).